I would say these flats run a ½ size larger. I am between a 6.5 and 7 in most shoes and the 7 was definitely too big. Even though, they have pointed toes, the toe area is roomy enough that it doesn't pinch my toes at all. As you can see in these photos, these fit me with no gap in the back of the heel. Also, I prefer shoes with minimal toe cleavage shown. It's just a personal preference. I know some people do like toe cleavage.
These are 100% man made. While I would always prefer leather shoes, I am not against faux leather at all. All my Target shoes are made from synthetic materials and they're quite comfy. These shoes do not require breaking in. I found them very comfy right out of the box.
I bought my Mom the exact same pair in brown and she is quite happy with them as well. They are so easy to pair with casual or work outfits. So far, I've worn them with skinny jeans, dresses and skirts. The snakeskin print on the back adds a bit of modern touch to these flats. If you're looking for a pair of flats with ankle straps, I highly recommend these. They fit my everyday needs, fill a void in my closet and are affordable.